General Cell Lines and Cell Cultures
ATCC NCI-H1618; Small Cell Lung Cancer; Human (Homo sapiens)
NCI-H1618 [H1618] is a cell line isolated from the lungs of a 55-year-old, White, female patient with stage E small cell lung cancer: carcinoma. This product has applications in cancer research.
ATCC Haemophilus parahaemolyticus; 536
Haemophilus parahaemolyticus strain 536 [NCTC 8479] was isolated from a chronic pulmonary infection. This bacterial type strain is known to produce the HhaI and HhaII restriction endonucleases.
ATCC Pfizer Pneumococcal polysaccharide powder Type 22 (d22F) 10mg
Purified pneumococcal polysaccharide type 22F (US type 22) is manufactured by Pfizer, Inc., for small-quantity distribution by ATCC. The pneumococcal polysaccharide type 22F can be used to assay for type-specific antibodies, research immune responses, and study immunodeficiencies.
ATCC Staphylococcus; haemolyticus; SM131 genomic DNA
Genomic DNA isolated from Staphylococcus haemolyticus strain SM 131. This bacterial strain is also available as ATCC Catalog No.: 29970™.
ATCC Magnaporthe oryzae; Guy11
An ampoule containing viable cells (may include spores and mycelia) suspended in cryoprotectant.
ATCC Campylobacter jejuni; subsp. jejuni
Campylobacter jejuni subsp. jejuni strain VPI H840 was isolated from the feces of a human child. This whole-genome sequenced bacterium is propagated under microaerophilic conditions and can be used in enteric disease research, infectious disease research, and media testing.
Eurofins Discoverx ChemiScreen LPA5/GPR92 Lysophospholipid Receptor Stable Cell Line, 2 vials. (HTS209C)
The ChemiScreen LPA5/GPR92 Lysophospholipid Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. LPA) based activation of LPAR5 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses LPAR5 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of LPAR5, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx ChemiScreen P2Y2 Purinergic Receptor Stable Cell Line, 2 vials. (HTS210C)
The ChemiScreen P2Y2 Purinergic Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. ATP, UTP) based activation of P2RY2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses P2RY2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of P2RY2, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx ChemiScreen LPA2 Lysophospholipid Receptor Stable Cell Line, 2 vials. (HTS207C)
The ChemiScreen LPA2 Lysophospholipid Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. LPA) based activation of LPAR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses LPAR2 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of LPAR2, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
Eurofins Discoverx Ready-to-Assay Y4 Neuropeptide Y Receptor Frozen Cells, 2 Vials of Cells. (HTS204RTA)
The Ready-to-Assay Y4 Neuropeptide Y Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. peptide YY) based activation of NPY4R GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses NPY4R alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of NPY4R, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx ChemiScreen AT2 Angiotensin II Receptor Membrane Preparation, 1 vial. (HTS208M)
The ChemiScreen AT2 Angiotensin II Receptor Membrane Preparation is derived from proprietary stable recombinant cells to ensure high levels of AGTR2 surface expression. ChemiScreen membrane preps can be used to screen for ligand binding affinities using a competitive radio-labeled ligand approach. Increased binding affinities will lead to higher radioactive signal. Membrane preps contain 1 mL of 1 mg/mL frozen membranes derived from a stably modified clonal cell line which was chosen for optimal receptor expression. For detailed product information, visit www.discoverx.com/membranepreps.
Eurofins Discoverx Ready-to-Assay LPA2 Lysophospholipid Receptor Frozen Cells, 2 Vials of Cells. (HTS207RTA)
The Ready-to-Assay LPA2 Lysophospholipid Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. LPA) based activation of LPAR2 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses LPAR2 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of LPAR2, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx Ready-to-Assay LPA5/GPR92 Lysophospholipid Receptor Frozen Cells, 2 Vials of Cells. (HTS209RTA)
The Ready-to-Assay LPA5/GPR92 Lysophospholipid Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. LPA) based activation of LPAR5 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses LPAR5 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of LPAR5, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx Ready-to-Assay OX1 Orexin Receptor Frozen Cells, 2 Vials of Cells. (HTS175RTA)
The Ready-to-Assay OX1 Orexin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. orexins) based activation of HCRTR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses HCRTR1 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of HCRTR1, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.